Our long time partners at Thermo Fisher Scientific asked us to create a video showcasing their newest electronic microscope the Arctis Cryo-FIB. We worked with Thermo Fisher Scientific to allow viewers a way to to visualize macromolecular structures in situ, inside the cell. Vitreous frozen cells are first thinned with a focused ion beam (FIB) microscope and then imaged in three dimensions using a transmission electron microscope (TEM). This transformative method has the power to revolutionize our understanding of cell biology, revealing the native cellular architecture with molecular clarity.