Our friends at Thermo Fisher Scientific reached out to have us produce a new video showcasing their newest electronic microscope the Arctis Cryo-FIB. Along with the Arctic machine, we visualized the macromolecular structures in situ, inside the cell. Vitreous frozen cells are first thinned with a focused ion beam (FIB) microscope and then imaged in three dimensions using a transmission electron microscope (TEM). This transformative method has the power to revolutionize our understanding of cell biology, revealing the native cellular architecture with molecular clarity.